“Game changer” in cancer research: Würzburg scientists achieve a breakthrough

During the creation and development of almost all of them cancer spielen MYC-Gene and their proteins play a central role. They do it uncontrolled growth and altered metabolism from tumor cells. And they help tumors trying to hide from the immune system.

MYC proteins also exhibit activity that was previously unknown—and the activity of MYC proteins Cancer research is now opening new doors: They also camp hollow spheres together, protective around special sensitive parts of the genome lay. If you destroy the bullets, the cancer cells will die. This was reported in the journal by a research team led by Martin Eilers and Elmar Wolf from the Institute for Biochemistry and Molecular Biology at the Julius Maximilian University of Würzburg (JMU). Nature. The professors are confident that their discovery will “Game changer” for cancer research is and new ways in cancer therapy allows

A weak point discovered in cancer cells – “hollow spheres” protect important enzymes

What the team discovered: They harvest the cells in the lab stressful conditions he held them fast growing tumor cells are similar, MYC proteins are stored in kernel in a dramatic way. They come together to form hollow spheres composed of thousands of MYC proteins. These surround and protect the individual, particularly sensitive regions in the genome – exactly the places where two types of enzymes collide can: enzymes that read DNA and enzymes that duplicate DNA. You can feel both two trains just imagine it DNA trace towards.

Hollow spheres thus prevent two “Enzyme-LoksThe Würzburg team was able to confirm this observation in cancer cells protective function from protein balls experimentally, he will figure it out Enzyme precipitation and consequently to multiple breaks in the DNA – which ultimately leads to death of cancer cells.

“These observations revolutionized our understanding of why MYC proteins are so essential tumor cell growth they are,” says Martin Eilers. The new findings also raise the question of whether medicines anyone can develop whom Making hollow spheres specifically prevent.

The basis for saving drugs – researchers found their own company

To push this development forward, Eilers and Wolf have one business Founded. Together with the university and partners from the pharmaceutical industry the search for drugs that interfere with the newly discovered functions of MYC proteins has begun. “That investors allowed us to start a company so quickly, that’s definitely not a given,” JMU professors say. They too take it as a sign that they have made a discovery that is very important promising Yippee.

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